“困坷”可以翻譯為：

**Hardship / adversity / difficulty**

具體選擇取決于語境：
- **Hardship** 更強調生活困苦、艱難境遇
- **Adversity** 側重逆境、厄運
- **Difficulty** 泛指困難、艱難狀態

例句：
- 他經歷了許多人生困坷 - He went through many hardships in life.
- 面對困坷，他從未放棄 - He never gave up in the face of adversity.

需要根據具體語境選擇最貼切的譯法。